Education:

• B.S., University of Southwestern Louisiana, University of Southwestern Louisiana, Biology/Chemistry, 1979
• B.S., University of South Alabama, Basic Medical Science, 1982
• Ph.D., University of South Alabama, Basic Medical Science, 1986

Professional Experience:

• University of North Dakota, Graduate School, Dean Appointed: 2001
• University of North Dakota, Medicine & Health Sciences, Pharmacology, Physiology & Therapeutics, Professor Appointed: 2001
• 1998-2001, Professor, University of South Alabama, Physiology
• 1995-1998, Associate Professor, University of South Alabama, Physiology
• 1993-1995, Associate Professor, Louisiana State University Medical Center at Shreveport, Physiology & Biophysics
• 1987-1993, Assistant Professor, Louisiana State University Medical Center at Shreveport, Physiology & Biophysics

Expertise and Research Interests:

• Vascular consequences of chronic portal hypertension
• Microcirculation
• Regulation of vascular smooth muscle contraction
• Lymphatic physiology
• Gene transfer to smooth muscle

Funding Received:

• Intestine in Chronic Portal Hypertension, $900,000, from 2000 to 2005

Publications:

• Payne MC, Zhang HY, Shirasawa Y, Koga Y, Ikebe M, Benoit JN, Fisher SA. Dynamic changes in expression of myosin phosphatase in a model of portal hypertension. American Journal of Physiology. Heart and Circulatory Physiology. 286(5): H1801-10, May 2004
• Shirasawa Y, Benoit JN. Stretch-induced calcium sensitization of rat lymphatic smooth muscle. American Journal of Physiology. Heart and Circulatory Physiology. 285(6): H2573-7, Dec 2003
• Nunamaker EA, Zhang HY, Shirasawa Y, Benoit JN, Dean DA. Electroporation-mediated delivery of catalytic oligodeoxynucleotides for manipulation of vascular gene expression. American Journal of Physiology. Heart and Circulatory Physiology. 285(5): H2240-7, Nov 2003
• Young JL, Benoit JN, Dean DA. Effect of a DNA nuclear targeting sequence on gene transfer and expression of plasmids in the intact vasculature. Gene Therapy. 10(17): 1465-70, Aug 2003
• Duan J, Zhang HY, Adkins SD, Ren BH, Norby FL, Zhang X, Benoit JN, Epstein PN, Ren J. Impaired cardiac function and IGF-I response in myocytes from calmodulin-diabetic mice: Role of Akt and RhoA. American Journal of Physiology. Endocrinology and Metabolism. 284(2): E366-76, Feb 2003
• Krenz M, Oldenburg O, Wimpee H, Cohen MV, Garlid KD, Critz SD, Downey JM, Benoit JN. Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells. Basic Research in Cardiology. 97(5): 365-73, Sep 2002
• Oldenburg O, Qin Q, Sharma AR, Cohen MV, Downey JM, Benoit JN. Acetylcholine leads to free radical production dependent on K(ATP) channels, G(i) proteins, phosphatidylinositol 3-kinase and tyrosine kinase. Cardiovascular Research. 55(3): 544-52, Aug 2002
• Martin JB, Young JL, Benoit JN, Dean DA. Gene transfer to intact mesenteric arteries by electroporation. Journal of Vascular Research. 37(5): 372-80, 2000
• Gardner JD, Benoit JN. Effects of capacitative calcium entry on agonist-induced calcium transients in A7r5 vascular smooth muscle cells. Journal of Biomedical Science. 7(4): 304-10, 2000
• Corboz MR, Ballard ST, Gao H, Benoit JN, Inglis SK, Taylor AE. Differential effects of furosemide on porcine bronchial arterial and airway smooth muscle. Journal of Applied Physiology (Bethesda, MD: 1985). 89(4): 1360-4, Oct 2000
• Taylor MS, Benoit JN. Effect of milrinone on small mesenteric artery vasoconstriction: role of K(+) channels. The American Journal of Physiology. 277(1 Pt 1): G69-78, Jul 1999
• Taylor MS, Gao H, Gardner JD, Benoit JN. Effects of IBMX on norepinephrine-induced vasoconstriction in small mesenteric arteries. The American Journal of Physiology. 276(4 Pt 1): G909-14, Apr 1999
• Benoit JN. Effects of alpha-adrenergic stimuli on mesenteric collecting lymphatics in the rate. The American Journal of Physiology. 273(1 Pt 2): R331-6, Jul 1997
• Wu ZY, Benoit JN. Altered vascular norepinephrine responses in portal hypertensive intestine: Role of PKA and guanylate cyclase. The American Journal of Physiology. 272(4 Pt 1): G831-7, Apr 1997
• Gao H, Korthuis RJ, Benoit JN. Hypoxia/reoxygenation selectively impairs alpha 1b-adrenoceptor function in small mesenteric arteries. The American Journal of Physiology. 271(5 Pt 1): G820-3, Nov 1996
• Yokoyama S, Benoit JN. Effects of bradykinin on lymphatic pumping in rat mesentery. The American Journal of Physiology. 270(5 Pt 1): G752-6, May 1996
• Yokoyama S, Korthuis RJ, Benoit JN. Hypoxia-reoxygenation impairs endothelium-dependent relaxation in isolated rat aorta. The American Journal of Physiology. 270(5 Pt 2): R1126-31, May 1996
• Gao H, Korthuis RJ, Benoit JN. Effects of hypoxia/reoxygenation on aortic vasoconstrictor responsiveness. Free Radical Biology & Medicine. 21(5): 591-600, 1996
• Wu ZY, Benoit JN. Effects of propranolol on intestinal microcirculation of normal and portal hypertensive rats. Journal of Hepatology. 22(6): 677-84, Jun 1995
• O'Callaghan DJ, Colle CF 3rd, Flowers CC, Smith RH, Benoit JN, Bigger CA. Identification and initial characterization of the IR6 protein of equine herpesvirus 1. Journal of Virology. 68(9): 5351-64, Sep 1994
• Wu ZY, Benoit JN. Nonreceptor-mediated intestinal vasoconstriction in portal hypertensive rats. The American Journal of Physiology. 267(1 Pt 2): H370-5, Jul 1994
• Negrini D, Ballard ST, Benoit JN. Contribution of lymphatic myogenic activity and respiratory movements to pleural lymph flow. Journal of Applied Physiology (Bethesda, MD: 1985). 76(6): 2267-74, Jun 1994
• Gao H, Korthuis RJ, Benoit JN. Effects of reactive oxygen metabolites on norepinephrine-induced vasoconstriction. Free Radical Biology & Medicine. 16(6): 839-43, Jun 1994
• Wu ZY, Benoit JN. Vascular NE responsiveness in portal hypertension: role of portal pressure and portosystemic shunting. The American Journal of Physiology. 266(3 Pt 2): H1162-8, Mar 1994
• Harris NR, Benoit JN, Granger DN. Capillary filtration during acute inflammation: Role of adherent neutrophils. The American Journal of Physiology. 265(5 Pt 2): H1623-8, Nov 1993
• Gawlowski DM, Benoit JN, Granger HJ. Microvascular pressure and albumin extravasation after leukocyte activation in hamster cheek pouch. The American Journal of Physiology. 264(2 Pt 2): H541-6, Feb 1993
• Joh T, Granger DN, Benoit JN. Endogenous vasoconstrictor tone in intestine of normal and portal hypertensive rats. The American Journal of Physiology. 264(1 Pt 2): H171-7, Jan 1993
• Benoit JN, Grisham MB, Mesh CL, Korthuis RJ, Granger DN. Hepatic oxidant and antioxidant systems in portacaval-shunted rats. Journal of Hepatology. 14(2-3): 253-8, Mar 1992
• Benoit JN, Zawieja DC. Effects of f-Met-Leu-Phe-induced inflammation on intestinal lymph flow and lymphatic pump behavior. The American Journal of Physiology. 262(2 Pt 1): G199-202, Feb 1992
• Benoit JN. Relationships between lymphatic pump flow and total lymph flow in the small intestine. The American Journal of Physiology. 261(6 Pt 2): H1970-8, Dec 1991
• Thomas SH, Joh T, Benoit JN. Role of bile acids in splanchnic hemodynamic response to chronic portal hypertension. Digestive Diseases and Sciences. 36(9): 1243-8, Sep 1991
• Joh T, Granger DN, Benoit JN. Intestinal microvascular responsiveness to norepinephrine in chronic portal hypertension. The American Journal of Physiology. 260(4 Pt 2): H1135-43, Apr 1991
• Mesh CL, Joh T, Korthuis RJ, Granger DN, Benoit JN. Intestinal vascular sensitivity to vasopressin in portal hypertensive rats. Gastroenterology. 100(4): 916-21, Apr 1991
• Grisham MB, Benoit JN, Granger DN. Assessment of leukocyte involvement during ischemia and reperfusion of intestine. Methods in Enzymology. 186: 729-42, 1990
• Benoit JN, Zawieja DC, Goodman AH, Granger HJ. Characterization of intact mesenteric lymphatic pump and its responsiveness to acute edemagenic stress. The American Journal of Physiology. 257(6 Pt 2): H2059-69, Dec 1989
• Granger DN, Benoit JN, Suzuki M, Grisham MB. Leukocyte adherence to venular endothelium during ischemia-reperfusion. The American Journal of Physiology. 257(5 Pt 1): G683-8, Nov 1989
• Sekizuka E, Benoit JN, Grisham MB, Granger DN. Dimethylsulfoxide prevents chemoattractant-induced leukocyte adherence. The American Journal of Physiology. 256(2 Pt 2): H594-7, Feb 1989
• Benoit JN, Granger DN. Increased hepatic oxygen consumption during alcohol withdrawal. Hepatology (Baltimore, MD). 8(5): 1171-2, 1988
• Yrle LF, Smith JK, Benoit JN, Granger DN, Korthuis RJ. Role of glucagon in intestinal hyperemia associated with early experimental diabetes mellitus. The American Journal of Physiology. 255(5 Pt 1): G542-6, Nov 1988
• Benoit JN, Granger DN. Intestinal microvascular adaptation to chronic portal hypertension in the rat. Gastroenterology. 94(2): 471-6, Feb 1988
• Meininger GA, Benoit JN, Ostrowska EZ, Muckleroy SK. Splanchnic circulatory changes during development of renal hypertension. The American Journal of Physiology. 253(2 Pt 1): G146-54, Aug 1987
• Korthuis RJ, Benoit JN, Kvietys PR, Laughlin MH, Taylor AE, Granger DN. Intestinal hyperemia in experimental diabetes mellitus. The American Journal of Physiology. 253(1 Pt 1): G26-32, Jul 1987
• Womack WA, Barrowman JA, Graham WH, Benoit JN, Kvietys PR, Granger DN. Quantitative assessment of villous motility. The American Journal of Physiology. 252(2 Pt 1): G250-6, Feb 1987
• Premen AJ, Go VL, Banchs V, Benoit JN, Kvietys PR, Granger DN. Renal hyperemia in portal hypertension is not mediated by gastrointestinal peptides. Regulatory Peptides. 16(1): 39-49, Dec 1986
• Benoit JN, Granger DN. Splanchnic hemodynamics in chronic portal hypertension. Seminars in Liver Disease. 6(4): 287-98, Nov 1986
• Benoit JN, Zimmerman B, Premen AJ, Go VL, Granger DN. Role of glucagon in splanchnic hyperemia of chronic portal hypertension. The American Journal of Physiology. 251(5 Pt 1): G674-7, Nov 1986
• Benoit JN, Womack WA, Korthuis RJ, Wilborn WH, Granger DN. Chronic portal hypertension: Effects on gastrointestinal blood flow distribution. The American Journal of Physiology. 250(4 Pt 1): G535-9, Apr 1986
• Adkison D, Hollwarth ME, Benoit JN, Parks DA, McCord JM, Granger DN. Role of free radicals in ischemia-reperfusion injury to the liver. Acta Physiologica Scandinavica. Supplementum. 548: 101-7, 1986
• Benoit JN, Womack WA, Hernandez L, Granger DN. 'Forward' and 'backward' flow mechanisms of portal hypertension. Relative contributions in the rat model of portal vein stenosis. Gastroenterology. 89(5): 1092-6, Nov 1985
• Korthuis RJ, Benoit JN, Kvietys PR, Townsley MI, Taylor AE, Granger DN. Humoral factors may mediate increased rat hindquarter blood flow in portal hypertension. The American Journal of Physiology. 249(4 Pt 2): H827-33, Oct 1985
• Kiel JW, Pitts V, Benoit JN, Granger DN, Shepherd AP. Reduced vascular sensitivity to norepinephrine in portal-hypertensive rats. The American Journal of Physiology. 248(2 Pt 1): G192-5, Feb 1985
• Benoit JN, Barrowman JA, Harper SL, Kvietys PR, Granger DN. Role of humoral factors in the intestinal hyperemia associated with chronic portal hypertension. The American Journal of Physiology. 247(5 Pt 1): G486-93, Nov 1984
• Anzueto L, Benoit JN, Granger DN. A rat model for studying the intestinal circulation. The American Journal of Physiology. 246(1 Pt 1): G56-61, Jan 1984
• Perry MA, Benoit JN, Kvietys PR, Granger DN. Restricted transport of cationic macromolecules across intestinal capillaries. The American Journal of Physiology. 245(4): G568-72, Oct 1983

Membership Information:

• American Physiological Society
• Microcirculatory Society

Other Expertise:

• Postdoctoral Fellowship, Texas A&M University, Microvascular Physiology, 1987