EDUCATION/TRAINING:

• Ph.D. University of Kansas
• Post-Doc: Harvard Medical School

RESEARCH INTERESTS:

I recently retired, and my laboratory is no longer active. However, I maintain interests in the areas I previously pursued - mammalian immunogenetics, transplantation, virally induced demyelinating diseases, and the immunogenetic and regulatory aspects of Theiler's Murine Encephalomyelitis Virus (TMEV) - induced demyelinating disease in particular. Recently I have concentrated more on writing - review articles, book chapters, and textbooks, and continue to participate in teaching at all levels as needed.

SELECTED PUBLICATIONS:

1. Melvold, R.W. (in preparation) Review of Immunology. In: Patterson’s Allergic Disease: Diagnosis and Management, 7th Ed.. L. Grammer and Paul Greenberger (Eds). Lippincott Williams & Wilkins, Philadelphia.
2. Melvold, R.W. and Sticca, R.P. (2007) Basic and tumor immunology – a review. Surgical Oncology Clinics of North America 16:711-735.
3. Doan, T, Melvold, R.W., Viselli, S. and Waltenbaugh C.R. (available 2007; copyright date 2008). Lippincott Illustrated Reviews – Immunology. Lippincott, Williams and Wilkins, Baltimore
4. Waltenbaugh, C.R. and Melvold, R.W. (2007) Adaptive Immune Defenses. In: Mechanisms of Microbial Diseases (4th ed.), Lippincott, Williams and Wilkins, Baltimore, pp. 90-115
5. Melvold, R.W. (2005) Transplantation. In: Encyclopedia of Life Sciences. John Wiley & Sons, Ltd, Chichester. http://www.els.net [doi:10.1038.npg/els.0003997].
6. Melvold, R.W. (2005) Major histocompatibility complex (MHC): Mouse. In : Nature Encyclopedia of Life Sciences. John Wiley & Sons, Ltd, Chichester http://www.els.net [doi:10.1038/npg.els.0003989 ]
7. Melvold, R.W. and Miller, S.D. (2005) Immunogenetics/resistance/ susceptibility to TMEV infection. In: Experimental Models of Multiple Sclerosis, E. Lavi and C.S. Constantiescu (Eds.), Kluwer Academic Publishers, London, pp, 629-644.
8. Doan, T., Melvold, R.W. and Waltenbaugh, C.R. (2005) Concise Medical Immunology. Lippincott, Williams and Wilkins, Baltimore.
9. Denton, P.W., Tello, C.M. and Melvold, R.W. (2004) CD8+ T cells reduce in vitro interferon-g production in Theiler’s Murine Encephalomyelitis Virus –induced demyelinating disease model . Multiple Sclerosis, 10:370-375.
10. Melvold, R.W. and Denton, P.W. : Prevention of demyelinating disease by adoptive T cell transfer. Recent Res. Devel. Neurosci. 1:1-13, 2004
11. Butterfield, R.J., Roper, R.J., Rhein, D.M., Melvold, R.W., Haynes, L., Ma, R.Z., Doerge, R., and Teuscher, C. (2003) Sex-specific QTL govern susceptibility to Theiler's murine encephalomyelitis virus-induced demyelination (TMEVD). Genetics 163 : 1041 - 1046.
12. Karls, K.A., Denton, P.W. and Melvold, R.W. (2002) Two distinct populations of CD4+ T cells involved with CD8+ T cells in regulation of TMEV-induced demyelinating disease. Multiple Sclerosis 8:469-474.
13. Melvold, R.W. (2002) Review of Immunology, In : Allergic Disease : Diagnosis and Management, R. Patterson (Ed.), 6th Edition, Lippincott Williams & Wilkins, Philadelphia, pp 1 - 24
14. Wang, K., Busker-Mannie, A.E., Hoeft, J., Vasquez, K., Miller, S.D., Melvold, R.W. and Waltenbaugh, C. (2001) Prolonged Hya-disparate skin graft survival in ethanol-consuming mice: correlation with impaired delayed hypersensitivity. Alcoholism: Clinical and Experimental Research 25 : 1542 - 1548.
15. Melvold, R.W. (2001) Transplantation. In: Encyclopedia of Life Sciences, London : Nature Publishing Group [www.els.net].
16. Melvold, R.W. (2001) Major histocompatibility complex (MHC): Mouse. In: Encyclopedia of Life Sciences, London : Nature Publishing Group [www.els.net].
17. Haynes, L.M., Vanderlugt, C.L., Dal Canto, M.C., Melvold, R.W. and Miller, S.D. (2000) A regulatory role for CD8+ T cells in resistance to TMEV-induced demyelinating disease. J. Neuroimmunol. 106 : 43 - 52, 2000.
18. Nicholson, S.M., Haynes, L.M., VanderLugt, C., Dal Canto, M.C., Miller, S.D. and Melvold R.W. (1999): The role of protective CD8+ T cells in resistance of BALB/c mice to TMEV-induced demyelinating disease: regulatory vs. lytic. J. Neuroimmunol., 98:136-146.
19. Melvold, R.W. (1998) BM mutants, In : Encyclopedia of Immunology, 2nd Ed., Roitt, I.M. and Delves, P.J. (Eds.), Academic Press, San Diego.
20. Melvold, R.W., Wang, K. and Kohn, H.I. (1997) Histocompatibility gene mutation rates in the mouse : a quarter century evaluation. Immunogenetics 47: 44 - 54.
21. Teuscher, C., Rhein, D.M., Livingstone, K.D., Paynter, R.A., Nicholson, S.M. & Melvold, R.W. (1997) Evidence that Tmevd2 and eae3 may represent either a common locus or members of a gene complex controlling susceptibility to immunologically mediated demyelination in mice. J. Immunol. 159 : 4930 - 4934.
22. Melvold, R.W. (1997) Review of Immunology, In : Allergic Disease : Diagnosis and Management, R. Patterson (Ed.), 5th Edition., pp. 1-26, Lippincott-Raven, Philadelphia.
23. Yun, T.J., Melvold, R.W. and Pease, L.R. (1997) A complex major histocompatibility complex D locus variant generated by an unusual recombination mechanism in mice. Proc. Natl. Acad. Sci. USA 94:1384-1389.
24. Melvold, R.W. (1996) H-2 mutants. In: Handbook of Experimental Immunology, 5th Ed. (D.M. Weir, L.A. Herzenberg, C. Blackwell and L.A. Herzenberg, Eds.), Blackwell Scientific Publications, Edinburgh, pp. 151.1-151.4.
25. Dal Canto, M.C., Kim, B.S., Miller, S.D. and Melvold, R.W. (1996) Theiler's murine encephalomyelitis virus (TMEV)-induced demyelination: A model for human multiple sclerosis. METHODS: A companion to Methods in Enzymology 10:453-461.
26. Nicholson, S.M., Dal Canto, M.C., Miller, S.D. and Melvold, R.W. (1996) CD8+ T lymphocytes provide protection against TMEV-induced demyelinating disease. J. Immunology 156 : 1276 - 1283.
27. Dal Canto, M.C., Melvold, R.W. and Kim, B.S. (1995) A hybrid between a resistant and a susceptible strain of mouse alters the pattern of TMEV-induced white matter disease and favors oligodendrocyte-mediated remyelination. Multiple Sclerosis 1:95-103.
28. Dal Canto, M.C., Melvold, R.W., Kim, B.S. and Miller, S.D. (1995) Two models of multiple sclerosis : Experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus infection (TMEV). A pathological and immunological comparison. J. Microsc. Res. Tech. 32:215-229.
29. Makino, M., Murphy, D.B., Melvold, R.W., Hartley, J.W. and Morse, H.C. III. (1995) Impact of MHC class I gene on resistance to murine AIDS. Scand. J. Immunogen. 42:368-372.
30. Nicholson S.M., Jokinen, D.M., Dal Canto, M.C., Kim, B.S. and Melvold, R.W. (1995) Genetic analysis of susceptibility of the SWR strain to TMEV-induced demyelinating disease. J. Neuroimmunol. 59:19-28.
31. Lipton, H.L., Melvold, R.W., Miller, S.D., Dal Canto, M.C. and Jensen, K. (1995) Mutation of a major histocompatibility class I locus, H-2D, leads to an increased virus burden and disease susceptibility in Theiler's virus-induced demyelinating disease. J. Neurovirology 1 : 138 - 144.
32. Miller, S.D., Karpus, W.J., Pope, J.G., Dal Canto, M.C. and Melvold, R.W. (1994) Theiler's murine encephalomyelitis virus-induced demyelinating disease. In : Animal Models for Autoimmune Diseases (I.R. Cohen, Ed.), Academic Press, New York, pp. 23-38.
33. Elliott, C., Wang, K., Miller, S.D. and Melvold, R.W. (1994) Ethylcarbodiimide (ECDI) as an agent for induction of transplant tolerance. Transplantation 58:966-968.
34. Nicholson, S.M., Peterson, J.D., Miller, S.D., Dal Canto, M.C. and Melvold, R.W. (1994) BALB/c substrain variation for susceptibility to Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. J. Neuroimmunol. 52:19-24.
35. Pullen, J.K., Tallquist, M.D., Melvold, R.W. and Pease, L.R. (1994) Recognition of a single amino acid change on the surface of a major transplantation antigen is in the context of self peptide. J. Immunol. 152:3445-3452.